Description
C-C motif chemokine 19(CCL19) is as known as CK beta-11, ELC, MIP3B and SCYA19.
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing.
May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs.
Binds to chemokine receptor CCR7.
Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes.
Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4